With this system, we observed preservation of cytoarchitecture attenuation of cell death and restoration of vascular dilatory and glial inflammatory responses, spontaneous synaptic activity, and active cerebral metabolism in the absence of global electrocorticographic activity. We have developed an extracorporeal pulsatile-perfusion system and a haemoglobin-based, acellular, non-coagulative, echogenic, and cytoprotective perfusate that promotes recovery from anoxia, reduces reperfusion injury, prevents oedema, and metabolically supports the energy requirements of the brain.
Here we describe the restoration and maintenance of microcirculation and molecular and cellular functions of the intact pig brain under ex vivo normothermic conditions up to four hours post-mortem. The brains of humans and other mammals are highly vulnerable to interruptions in blood flow and decreases in oxygen levels.
Note for international applicants with visa requirements: The process may take up to 90 days. Hours: Approximately 40 hours per week and flexible schedule. Track record with several publications, and prior experience in Matlab and python are a requirement.Īpplication Instructions: Please email your CV and personal statement to the principle investigator. This position is ideal for students/post-graduates with interests in neuroscience, signal and image processing.
Requirements/Qualifications: Previous research experience is required. Candidates will contribute in many ways to the research project, typical responsibilities include but not limited to: Conduct literature reviews, collect and analyze data, consent the patients, run Matlab routines among others. Candidates may have the opportunity to apply for their own grants depending on level of training to support further funding. Besides routine job duties, candidates will have the opportunity to attend graduate-level coursework in neuro-science, biomedical, and signal and image processing. The center has pioneered modernization and the re-introduction of stereo-EEG in the United States. This is a great opportunity to work by the side of the PI and a renowned neuro-surgeon (TBA) with expertise in functional neurosurgery and epilepsy in particular. The research involved combine multi-modalities to advance our understanding of epileptic and functional networks with primary focus on intracranial EEG. The center has been on the cutting edge in pioneering many advanced functional imaging and surgical techniques. The Comprehensive Epilepsy Center is internationally recognized as a leader in treatment of medically intractable epilepsy. Pitt comprehensive Epilepsy Center is one of the leading and most modern in the world. Job Description: This is a great opportunity in one of the largest schools in the United States, reputable for an amazing research environment. Position Type: Full-time for 1-year renewable based on performance and satisfactory academic performance as defined by the principle investigator Location: Pittsburgh, Pennsylvania Organization Contact: PI Rafeed Alkawadri Title: Post-graduate research associate. Organization: The University of Pittsburgh, Department of Neurology